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Start of a clinical proof-of-concept study to characterize postprandial glucose flux

The Hannover Medical School (MHH) with its team for early clinical trials/CRC Core Facility (Prof. Schindler) has started a new proof-of-concept trial in cooperation with the Braunschweig Integrated Centre for Systems Biology (BRICS), department of biochemistry and bioinformatics of the Technical University of Braunschweig (Prof. Karsten Hiller) and the Luxembourg Centre for Systems Biomedicine (LCSB). The study aims to validate a new clinical investigational method for characterizing post-prandial glucose flux. After oral administration of the stably labeled, non-radioactive glucose isotope 13C, glucose metabolites are analyzed and absolute flux values for glucose production, glucose disappearance and gluconeogenesis on a whole-organism scale can be calculated. Compared with clinically established routine methods, the new methodology provides further insights into glucose consumption and gluconeogenesis. The new method might enable a more detailed investigation of the pharmacokinetics and -dynamics of diabetes drugs in the future.

 

Contact:
Prof. Dr. Christoph Schindler
Hannover Medical School (MHH)
Head of MHH CRC Core Facility
Phone: +49 511 5350 8300
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