Inflammation Monitoring

Monitoring of inflammatory processes

For detailed observation and monitoring of processes in the lungs, our repertoire includes a variety of invasive and noninvasive methods that are being constantly improved.

Especially in clinical trials and proof-of-concept studies, it is often necessary to measure airway inflammation for monitoring diseases of the airways. This can be done by invasive bronchoscopic methods (e.g. bronchoalveolar lavage (BAL), bronchial biopsies) or by noninvasive methods such as sputum analysis and measuring nitric oxide (FeNO) concentrations in exhaled breath. We also test new methods and validate these in studies with patients suffering from respiratory diseases.

For this purpose, we have at our disposal established challenge models (ozone, LPS, allergen) that we use to temporarily induce specific inflammatory processes in healthy volunteers or patients with allergic sensitization, followed by sputum analysis to evaluate and compare the inflammations. Such direct comparison permits early assessment of the clinical value of new methods. This approach can also be used to test new methods developed by third parties, to test biomarker candidates, or to develop new medical devices.


  • Induced sputum
  • Bronchoalveolar lavage (BAL)
  • Bronchial biopsies (incl. pathology)
  • Bronchial brushings
  • Exhaled NO
  • Exhaled breath analysis
    • Volatile organic compounds
    • Exhaled particles



Prof. Dr. med. Jens Hohlfeld
Fraunhofer ITEM
Division Director
Phone +49 511 5350-8101
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Dr. med. Dipl.-Kfm. Philipp Badorrek
Fraunhofer ITEM
Head of Department
Phone +49 511 5350-8130
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